NHLBI
The UW NHLBI Center- Gene Expression Arrays for Mammalian Cell Biology
PI: Daniel Sabath - Associate Professor, Laboratory Medicine
Co-PI: Roger Bumgarner - Assoicate Professor, Microbiology

In August of 2001, the University of Washington was awarded a four year grant from the National Heart Lung and Blood Institute (NHLBI) of the National Institutes of Health to develop an Array Center for NHLBI investigators at the University of Washington. This center leveraged the capabilities of a pre-existing array facility - The Center for Expression Arrays (CEA), in the Department of Microbiology.

Specifically, the NHBLI center provides:
1) access to the highest quality DNA arrays and array services for the human, mouse and rat genomes in an environment of rapidly changing technologies.
2) Provides data analysis support and training to researchers.
3) Develops and provides statistically based methods of experimental design and data analysis

NHLBI investigators access the center by writing "mini-proposals" which are then submitted to a local review team. After review (and typically suggested revisions and improvements), samples are processed by a technician assigned to the center and data analysis support is provided through the center.
Research Activities
Bioinformatics
Virology/Bacteriology
Centers
 - UW Toxico Genomics
 - UW - NHLBI Center
 - Center for Pathway Inference Software
Recent Publications
-- Nature Genetics - Integrating large-scale functional genomic data...

-- Nature Biotechnology - Min info spec for in situ hybridization...

-- Nature Biotechnology - Direct multiplexed measurement of gene expression...

-- J Virology - Attenuation of the type I interferon response...

-- J Virology - Independent and cooperative antiviral actions of beta interferon...

-- Carcinogenesis - Comparative genomics of susceptibility to mammary carcinogenesis...

-- OMICS - What is the best reference RNA?...

-- J Virology - Human rhinovirus attenuates the type I interferon response...

-- Science - Rhesus Macaque Genome Sequencing and Analysis Consortium...

-- Cell Microbiology - Hierarchical gene expressio profiles of HUVEC...